MGMIHS - SBS | Faculty & Staff

Name	Qualification	Designation	Date of Joining
Mrs. Supriya Pawar	B.A, M.B.A	Sr. Clerk.	14/07/2011
Mrs. Poonam Patil	M.Sc	Lab Techn.	12/04/2011
Mrs. Kajal Bandhankar	B.Com	Juniour Accountant	12/04/2011
Mrs. Shital Salunkhe	B.Sc Medical Laboratory Technology	Research Assistant	01/05/2021
Mr. Vikas Utekar	B. Com	Clerk	1/11/2020
Mr. Mayur Harname	S.S.C	Lab Atten.	22/04/2013
Mr. Runit Patil	S.S.C	Lab Atten.	02/06/2014

Name	Qualification	Designation
Dr. Anjali Sabnis	MD Anatomy	Professor & HOD
Dr. Parineeta Samant	Ph.D (Biochemistry)	Associate Professor
Dr. Deepika Sareen	MD Ansthesia	Professor & HOD
Ms. Minal Kanse	B.Sc. Perfusion Technology	Perfusionist
Mr. Amol Gole	Persuing M.Sc Dialysis Technology	Dialysis Technologist
Mr. Ramesh Sharma	D.E.H.M	Dialysis Technologist

Sr. No.	Name	Designation
	Dr. Mansee Thakur	Incharge Director & Professor
	Dr. Raman P. Yaday	Professor
	Dr. Himanshu Rajat Gupta	Assistant Professor
	Dr. Priyanka Pareek	Assistant Professor
	Mr. Yogesh Navalsing Patil	Tutor
	Mrs. Chandana Charudatta Kulkarni	Tutor
	Mrs. Priyanka Rathod	Tutor
	Mr. Rohit Indrakumar Gupta	Tutor
	Mr. Pratik Sanjay Morade	Tutor
	Mr. Neelan1 Yeram	Tutor
	Mrs. Anamika Mahesh Chalwadi	Tutor
	Ms. Patcy Bellarbin	Tutor
	Mr. Subodh Rahate	Tutor
	Ms. Rafiya Sangameshwari	Lecturer
	Ms. Shruti Patil	Tutor
	Ms. Pranita Utekar	Tutor
	Mrs. Anjali Rajendra Singh	Tutor

Dr. Mansee Thakur, Professor & HOD, Department of Medical Biotechnology, Director, MGM School of Biomedical Sciences, MGMIHS, Navi Mumbai.

Affiliation: Department of Medical Biotechnology, MGM School of Biomedical Sciences, MGMIHS, Navi Mumbai.

Research gate: https://www.researchgate.net/profile/Mansee-Thakur
Google scholar: https://scholar.google.co.in/citations?user=zD5iO6MAAAAJ&hl=en
LinkedIn: linkedin.com/in/dr-mansee- thakur-4781b076
ORCID ID: https://orcid.org/0000-0003-4743- 1476
Scopus ID: 57191281886

ACADEMIC BACKGROUND:

Ph. D in Biotechnology, Pt. Ravishankar Shukla University Raipur (C.G.), 2007.
P.G. DIPLOMA IN BIOINFORMATICS Bioinformatics institute of India, Noida with A grade in 2005
Master’s degree in Biotechnology, Pt. Ravishankar Shukla University Raipur (C.G.), 2001 with 73%.
Bachelor’s degree in Microbiology (Microbiology, Chemistry, Zoology), Osmania University, Hyderabad, 1999 with 78%.

RESEARCH PROFILE & EXTRAMURAL FUNDING:

Dr. Thakur has been closely interacting with eminent scientists from BARC, BITS-Goa, and RRCAT-Indore. Her thrust area of research is to develop a hand-held MGM-TB Detection System (MGM- TBDS) in service of India, for which she received funds worth of Rs.50 lakh from Board of Research in Nuclear Science (BRNS).
In addition, she is actively working to understand the mechanisms, toxicity studies for various nanoparticles in zebrafish model. For the study using Homeopathy medicines she had received Rs.25 lakh rupees funds from BRNS.
Recently she has also received Rs. 76 Lakh rupees fund from Department of Health Research (DHR) for conducting training two types of National level for Molecular Diagnostics and Zebrafish studies.
She is also involved in spirituality and is a certified Heartfulness Meditation Trainer associated with various activities of Heartfulness Institute- not for profit organization providing services through various initiative Village connect (V-Connect), School connects (S-connect), Corporate connect (C- connect), plantation and Meditation Drive.

PROFESSIONAL EXPERIENCE:

Director, MGMSBS, MGMIHS Navi Mumbai
Member of Academic Council, MGMIHS
Member of Faculty of Medicine Council, MGMIHS
Member of Examination Committee, MGMIHS
Chairperson of Board of Studies MGMSBS, MGMIHS
Chairperson of CBCS Committee at MGMIHS
Research Officer in MGM Central Research Lab, MGMIHS
External Expert in BOS Member and Research Committee at Pillai College, CKT College, Amity university, Mumbai University

CORE COMPETENCY:

Nodal officer of ICMR for COVID-19 RT PCR diagnosis.
Extensive experience in research designing, project writing, and execution.
Established Molecular Lab, Zebra fish Lab at MGM Medical College, Kamothe Navi Mumbai.
In process of establishing Integrated Research in MGMSBS.
Recognized guide for M.Sc. and Ph.D. in Medical Biotechnology & Medical Genetics, MGMIHS.

PHD SUPERVISED- 08; PURSUING 05

(Recognized Guide for Biotech & Genetics)

M.Sc. DISSERTATION SUPERVISED- 50+

SELECTED AWARDS:

Young Scientist award in Biotechnology at 2nd Chhattisgarh Young Scientist Congress.
Awarded Gold Medal in Biotechnology for Post Graduate Studies.
Recipient of Department of Biotechnology, New Delhi – Fellowship (Govt. of India).
Felicitated by Miss Aditi Tatkare, State Guardian Minister, Raigad & Ms Nidhi Chaudhari, District Collector, and Raigad for Setting up of RTPCR lab at Alibaug for CoVID Testing.
Awarded the Kamala Bhagwat Sohonie Science Shikshika / shodhkartri Mention 2022 on occasion of the International Day of Women & Girls in Science 2022.
Stree Jyoti Award by Heartfulness Popular Wellness Institute and NMMC in Enthusiasm in 2023.
Inspiring Woman Award 2022, organized at the National level under the joint aegis of Fourth Screen Education and Pandit Dharma Prakash Sharma Memorial Charitable Trust.

RESOURCE PERSON:

Given 10+ lectures as a resource person in national and international forums.

OTHER RESPONSIBILITIES:

Played a major role in getting NABL accreditation & ICMR approval for COVID-19 Diagnosis at MGM Medical college Central Laboratory.
Seminar/ Workshop/Orientation Programme Organized
30 + workshops/ seminars conducted on interdisciplinary research, IPR & Industry Academia Innovative practices during the last three years.

PATENTS (04)- 03 GRANTED 01 PUBLISHED:

Patent No: Application no: 201721023124-- Sensor-Based Inflatable Device.
Patent No: 415484 - Micro-trench-based biochip device for screening of infectious diseases.
Published no: 98915 - Design patents for Custom-built Electrophoresis system.
Application no: 201721023794 - A Biological Safety Cabinet and A Kit Thereof.

COPYRIGHTS -40+

BOOKS & CHAPTERS:

Books:

Himanshu Gupta, Mansee Thakur, Dipty Singh. Reproductive toxicity assessment of gold and silver nanoparticle.2018 (ISBN-978-61-383399-4-6)
Antimicrobial Resistance Underlying Mechanisms and Therapeutic Approaches Editors: Kumar, V., Shriram, V.,Paul A,ThakurM.(Eds.https://www.springer.com/gp/book/9789811631191 ISBN 978-981-16-3119-

Chapters:

Thakur M, Poojary S, Thakur KS, Kumar V. Antimicrobial Potentials of Zinc and Iron Oxide Nanoparticles. In Nano-Strategies for Addressing Antimicrobial Resistance 2022 (pp. 353-368). Springer, Cham.
Gupta H, Kadam N, Patil S, Thakur M. Homeopathy as a Nanomedicine: A Scientific Approach. In Engineered Nanomaterials for Innovative Therapies and Biomedicine 2022 (pp. 405-424). Springer, Cham.
Niharika Swain, Rashmi Hosalkar, Mansee Thakur, Antony Herold Prabhu. Hallmarks of Cancer: Its Concept and Critique. Microbes and Oral Squamous Cell Carcinoma. 2022. 55-68.
Niharika Swain, Jay Gopal Ray, Rashmi Hosalkar, Mansee Thakur, Kapil Singh Thakur. Role of Inflammation and Infection in Oral Squamous Cell Carcinoma. Microbes and Oral Squamous Cell Carcinoma.2022. 69-74
Navalsing PY, Kumar SV, Vinod SA, Harapriya K, Kapil TM. Development of Low-Cost PCR Product Detection System for Screening and Diagnosis of Infectious Diseases. In Techno-Societal 2020 2021 (pp. 923-933). Springer, Cham.
Thakur M, Poojary S, Swain N. Green Synthesis of Iron Oxide Nanoparticles and Its Biomedical Applications. Nanotechnology Applications in Health and Environmental Sciences. 2021:83-109
Patil Y, Thakur M. Development and Validation of Indigenously developed DNA Detection System for
M. tuberculosis. International Journal on Emerging Technologies 11(3): 182-187. 2020
Swain N, Routray S, Hosalkar RM, Iyer J, Thakur M. Keratin. In: Encyclopedia of Signaling Molecules. Springer New York; 2018. p. 1–8.
Pai G, Thakur M, Kar H, Joshi DS. Validation of in House PCR Using IS6110 for Detection of M. tuberculosis and Its Comparison with ZN Staining, Cultures and RT PCR Kit Methods. InTechno-Societal 2016, International Conference on Advanced Technologies for Societal Applications 2016 Dec 20 (pp. 599-609). Springer, Cham
Kulkarni S, Abraham PS, Mohanty N, Kadam NN, Thakur M. Sustainable raft based hydroponic system for growing spinach and coriander. In Techno-Societal 2016, International Conference on Advanced Technologies for Societal Applications 2016 Dec 20 (pp. 117-125). Springer, Cham.

PUBLICATIONS-50 +

Philip ST, Thimmapuram J, Gupta H, Fatima TH, Rahate S, Yeram N, Thakur K, Thakur M. An Experimental Prospective Study on Effectiveness of Brief Heartfulness-Based Start ‘U’p Program on Anxiety and Perceived Stress in Allied Health Students. Journal of Health and Allied Sciences NU. 2023 May 1.
Pathak C, Vaidya FU, Waghela BN, Jaiswara PK, Gupta VK, Kumar A, Rajendran BK, Ranjan K. Insights of Endocytosis Signaling in Health and Disease. International Journal of Molecular Sciences. 2023 Feb 3;24(3):2971.
Bhide R, Madasu D, Patil P, Dayal N, Koppaka O, Ather S, Thakur M. Formulation, Characterization and In Vitro Evaluation of ProShine MBTMGMIHS Herbal Sunscreen cream containing Flower Extract. Research Journal of Pharmacy and Technology. 2023 Mar 31;16(3):1309-13.
Panikar SA, Sharma S, Sureshkumar K, Dubey S, Thakur MK. Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery. MGM Journal of Medical Sciences. 2023 Jan 1;10(1):77.
Himanshu Gupta, Nitin Kadam, Shankargouda Patil, Mansee Thakur. Homeopathy as a Nanomedicine: A Scientific Approach. Engineered Nanomaterials for Innovative Therapies and Biomedicine. 2022. 405-424
Kini V And Awachar S Dekate K, Thakur M, Walekar S, Choudhari S. Evaluation of Immune Expression of Stat3 as Early Event for Cellular Alteration in Tobacco Stressed Oral Mucosa. International Journal of Biology, Pharmacy and Allied Sciences.2022; 11(1): 216-227.
Badodekar N, Mishra S, Telang G, Chougule S, Bennur D, Thakur M, Vyas N. Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review. Regenerative Engineering and Translational Medicine. 2022 Aug 8:1-31.
Mistry K, Sardar SD, Alim H, Patel N, Thakur M, Jabbarova D, Ali A Philip ST, Thimmapuram J, Gupta H, Fatima TH, Rahate S, Yeram N, Thakur K, Thakur M. An Experimental Prospective Study on Effectiveness of Brief Heartfulness-Based Start ‘U’p Program on Anxiety and Perceived Stress in Allied Health Students. Journal of Health and Allied Sciences NU. 2023 May 1.
Pathak C, Vaidya FU, Waghela BN, Jaiswara PK, Gupta VK, Kumar A, Rajendran BK, Ranjan K. Insights of Endocytosis Signaling in Health and Disease. International Journal of Molecular Sciences. 2023 Feb 3;24(3):2971.
Bhide R, Madasu D, Patil P, Dayal N, Koppaka O, Ather S, Thakur M. Formulation, Characterization and In Vitro Evaluation of ProShine MBTMGMIHS Herbal Sunscreen cream containing Flower Extract. Research Journal of Pharmacy and Technology. 2023 Mar 31;16(3):1309-13.
Panikar SA, Sharma S, Sureshkumar K, Dubey S, Thakur MK. Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery. MGM Journal of Medical Sciences. 2023 Jan 1;10(1):77.
Himanshu Gupta, Nitin Kadam, Shankargouda Patil, Mansee Thakur. Homeopathy as a Nanomedicine: A Scientific Approach. Engineered Nanomaterials for Innovative Therapies and Biomedicine. 2022. 405-424
Kini V And Awachar S Dekate K, Thakur M, Walekar S, Choudhari S. Evaluation of Immune Expression of Stat3 as Early Event for Cellular Alteration in Tobacco Stressed Oral Mucosa. International Journal of Biology, Pharmacy and Allied Sciences.2022; 11(1): 216-227.
Badodekar N, Mishra S, Telang G, Chougule S, Bennur D, Thakur M, Vyas N. Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review. Regenerative Engineering and Translational Medicine. 2022 Aug 8:1-31.
Mistry K, Sardar SD, Alim H, Patel N, Thakur M, Jabbarova D, Ali A. Plant based proteins: Sustainable alternatives. Plant Science Today. 2022 Oct 1;9(4):820-8.
Jadhav SR, Thakur M, Gupta H. Biosynthesis of silver nanoparticles using mushroom extract and its toxicity assessement in zebrafish embryos. Vegetos. 2022 Oct 1:1-8.
Dekate K, Barpande S, Tupkari J, Thakur M, Swain N. Identification of genetic instability in peripheral blood lymphocyte of oral squamous cell carcinoma patients assess by comet assay. Journal of Oral and Maxillofacial Pathology: JOMFP. 2022 Apr;26(2):284.
Swain N, Thakur M, Pathak J, Patel S, Hosalkar R, Ghaisas S. Altered immunoexpression of SOX2, OCT4 and Nanog in the normal-appearing oral mucosa of tobacco users. Dental and Medical Problems. 2022 Jul 1;59(3):389-95.
Jadhav S, Waingankar P, Thakur M. Community mapping of COVID-19 cases admitted from April to June 2020 at a tertiary health care hospital in Raigad district in Maharashtra, India. MGM Journal of Medical Sciences. 2022 Apr 1;9(2):177.
Babar P, Samant S , Thakur M . Isolation of Stenotrophomonas pavanii DSM 25135(T) from Textile Effluent and Bioremediation of Carcinogenic Dye Basic Fuchsin in Free Cell vs Immobilized Cell System. IJEP. 2022 Jan 42(1): 25-32. Plant based proteins: Sustainable alternatives. Plant Science Today. 2022 Oct 1;9(4):820-8.
Jadhav SR, Thakur M, Gupta H. Biosynthesis of silver nanoparticles using mushroom extract and its toxicity assessement in zebrafish embryos. Vegetos. 2022 Oct 1:1-8.
Dekate K, Barpande S, Tupkari J, Thakur M, Swain N. Identification of genetic instability in peripheral blood lymphocyte of oral squamous cell carcinoma patients assess by comet assay. Journal of Oral and Maxillofacial Pathology: JOMFP. 2022 Apr;26(2):284.

Dr. Raman P. Yadav, Professor, Department of Medical Biotechnology, MGM School of Biomedical Sciences, & Technical Director, MGMIHS OMICS Research Center, MGMIHS, Navi Mumbai.

Research Interests

Drug discovery, reversal of drug resistance, biomarker and diagnostics, nanomaterials & quantum dots, nanobiotechnology, enzymology, green technology etc.

Academic Background

Ph. D. (Microbiology), University of Delhi,1995
M.Sc. (Zoology), University of Delhi,1986

Professional experience:

Professor in Department of Medical Biotechnology, MGM School of Biomedical Sciences, MGMIHS, Navi Mumbai (1stSeptember 2012-to till date).
Professor in the Department of Biotechnology, MGM College of Engineering & Technology, Navi Mumbai (April 2012-August 2012).
Chief Scientific Advisor, Goodrich Carbohydrates Ltd. Karnal, Haryana (2011).
Research Leader, Enzymology, Reliance Life Sciences Pvt. Ltd. Navi Mumbai (2006-2010).
Research Scientist/Leader, Drug Discovery and Development, Reliance Life Sciences Pvt. Ltd. Navi Mumbai (2002-2006).
CSIR-Senior Research Associateship (Scientists Pool Scheme), worked at National Institute of Immunology (NII), New Delhi (1998-2001).
Consultant /RA, National Institute of Immunology (NII), New Delhi (1996-1998).
Lecturer, Department of Microbiology, Swami Shardhanand College, University of Delhi (1994-1996).

Recent Selected Publications

Bela M. Agarwal, Raman P. Yadav, Sanketa D. Tambe, Chandana C. Kulkarni, & Rajani P. Mullerpatan. 2021. Evaluation of Early Knee Osteoarthritis Using Biomechanical and Biochemical Markers. Critical ReviewsTM in Biomedical Engineering, 49(6):29 - 39
Harshita Mohanty, Samir Pachpute, Raman Yadav. 2021.Mechanism of drug resistance in bacteria: efflux pump modulation for designing of new antibiotic enhancers. Folia Microbiologica, 66(5):1-13
Priyanka Rathod & Raman Yadav. 2021. Anti-diabesity potential of various multifunctional natural molecules. Journal of Herbal Medicine. 27(10):100430
Priyanka Rathod, Chandana Kulkarni, Raman Yadav 2021. Anti-diabesity principle from the seeds of Phyllanthus emblica L. Indian Drugs.57(12): 41-50
Dr. Bharat Gupta, Dr. Raman P Yadav, Dr. Sabita M Ram, Dr. Neha Patil. 2021. Effect Of Non-Surgical Periodontal Therapy On Levels Of Salivary MMP- 8 In Chronic Periodontitis Patients: Systematic Review. Nat.Volatiles & Essent. Oils.8(4): 16229-16234
Amita A Bhagit, Sveeta V Mhatre, Raman P Yadav. 2020.Proteome mediated synthesis of biocompatible green fluorescence cerium oxide quantum dots with enhanced antioxidant activity. Advanced Science, Engineering and Medicine.12(6):831-839
Mhatre S., Bhagit A. and Yadav R. P. 2019. Proteinaceous Pancreatic Lipase Inhibitor from the Seed of Litchi chinensis. Food Technology and Biotechnology. 57(1):113-118
Rinkey Shahu , Priyanka Rathod, Chandana Kulkarni Raman Yadav 2018. Pancreatic lipase inhibitory and antioxidant activity of methanolic extract of florets of aster species. Indian Drugs. 55(12):60-68
Abhijit Naik, Saurabh Shrivastava, Naheed Abidi, Raman Yadav, Prachi Shah Yash gala.2018.Study of tear proteins for possible biomarker in primary open-angle glaucoma. J of Clinical Ophthalmology and Research. 6(2):66-70
Mhatre S., Bhagit A. and Yadav R. P.2017.In vitro studies of some edible spices on pancreatic lipase inhibitory activity. Indian drugs. 54: 62-68

Patents (Granted)

Patent Number No.325554, granted on 22nd November 2019 - Quantum dot powered IP-10 antibody based kit for latent TB and TB antigen. Yadav,Raman Prasad, Kadam, Sudhirchandra Nanasaheb, Kadam, NitinNanasaheb, Bhagit, AmitaAnant. MGM Institute of Health Sciences, Sector -1, Kamothe, Navi Mumbai-410209, Maharashtra, India
United States Patent (Patent No.: US 7355, 055 B2), April 8, 2008. Compounds for treatment of lipase mediated disease. Upadhyay Shskti, Yadav Raman, Vijay Gangan &Yogesh Kanekar. Reliance Life Sciences Pvt.Ltd. Maharashtra (IN)
United States Patent (Patent No.: US 7368,529 B2), May, 6, 2008. Agent and composition comprising the same for inhibiting lipases and phospholipases in body fluid, cells and tissues. Shakti. N Upadhyay, Raman P Yadav, Arif Ansari & Hari Narayan Rao. Reliance Life Sciences Pvt. Ltd. Maharashtra (IN)
United States Patent (Patent No.: US 5856487), January, 5, 1999. Application of protoberberine alkaloid, berberine an immunosuppressive agent. Upadhyay Shakti N &Yadav Raman Prasad, National Institute of Immunology, New Delhi
Indian Patent Number: 212533, 4th December, 2007, PCT International Classification Number- A61K 35/78, Formulation comprising a protein enriched fraction obtained from a plant of Tinospora species". Shakti Nath Upadhyay ,NarvulaKrishnammanaidu Saraswathi, Raman Prasad Yadav, NII, Aruna Asaf Ali Marg, New Delhi-110067, India.

Selected awards

VIRA 2016 Distinguished Scientist Award for contribution and achievement in the field of Biotechnology, Venus International Foundation, India.
1998, AMI, “Fermentation and Food Microbiology Young Scientist Award”.39th Annual conferences of Association of Microbiologists of India, Mangalore.

Recognitions

Adjunct Professor (Honorary)-2021 to till date. Institute of Chemical Technology, Mumbai, Elite Status and Center of Excellence, Govt. of Maharashtra, Public Funded University, India
Former member, Biotechnology Task Force (2011-12) of PHD Chamber of Commerce and Industry. New Delhi
Member of Academic Council, MGMIHS, Navi Mumbai.
Member, Ethical committee for Research on Human Subjects, MGMIHS, Navi Mumbai
Member, Editorial Review Board, MGM Journal of Medical Sciences
Ph.D. guide (Medical Biotechnology, Molecular Biology), MGMIHS, Navi Mumbai

Other responsibilities

Director, MGMIHS Incubation and Innovation Center, MGMIHS, Navi Mumbai
Technical Director, MGM Central Research Laboratory, MGM Medical College & Hospital/MGMIHS, Navi Mumbai
Head of Department, M.Sc. Molecular Biology, MGM school of Biomedical Sciences, MGMIHS, Navi Mumbai.
Convener, Institutions Innovation Council (IIC), MGMIHS, Navi Mumbai (established as per the norms of Innovation Cell, Ministry of HRD, Govt. of India during IIC Calendar year 2019-20).

Location: MGMIHS OMICS Research Center,1st floor, MGM Medical College, Navi Mumbai

Research gate: https://www.researchgate.net/profile/Raman_Yadav4

Google Scholar: Dr. Raman Yadav

LinkedIn: https://in.linkedin.com/in/dr-raman-p-yadav-8062b8b5

Professor
Ph.D. (Biochemistry); M.Sc. Biotechnology
E-mail: cmpathak@mgmuhs.com
Mobile No: +91-8140169410

H Index: 20
i10 Index: 34
Citations: 1184
Cumulative Impact factor of publications: 225
Google Scholar: https://scholar.google.com/citations?user=iAfnZlAAAAAJ&hl=en
Scopus id: 57220389783

RESEARCH EXPERIENCE:

21 Years (15 years Post Ph.D.)

Research Interests:

Cancer Biology, Diabetes, Programmed Cell death Signaling in Cancer, Nanoparticle based Drug delivery, Oxidative stress, Pain & Inflammation, and Molecular basis of diseases i.e., Cancer, Sepsis, Diabetes, Osteoporosis and Cardiovascular etc

HONOURS/AWARDS:

2022 INSO Outstanding Scientist Award
2017 Excellence in Research Award
2011 DST Young Scientist Award
2010 DBT Rapid Grant for Young Investigator
2008 Dr. D.S. Kothari, UGC Postdoctoral Fellowship Award
2004 ICMR-Senior Research Fellowship Award

RESEARCH GRANTS:

Deciphering the role of FADD and HMGB1 in subset to the regulation of NLRP3 inflammasome and cell proliferation in context to anti-cancer drug resistance (2017-2020), Principal Investigator, funded by SERB, Gov of India Rs. 37.33 Lakhs.
Study the ubiquitination of FADD and cFLIP and their response on cell death, survival and inflammatory signaling in cancer. (2015-2019), Principal Investigator, funded by DBT, Gov of India Rs. 25.00 Lakhs.
Study the role of cFLIP in apoptosis and autophagic signaling by NF-kB pathway in cancer. (2014-2018), Principal Investigator, funded by GSBTM, Gov of Gujarat, Rs. 15.86 Lakhs.
Investigating the functional relationship of RAGE in cancer and special focusing to its regulation by SiRNA. Principal Investigator, (2012-2015) funded by DST, Gov of India Rs. 20.30 Lakhs
Targeting the mitochondria dependent and independent apoptotic signaling by Nanoparticulate drug to induce apoptosis in cancer cells. (2011-2015). Principal Investigator, funded by DBT, Gov of India Rs. 53.37 Lakhs.
Unrevealing the cross talk between inflammation and apoptosis: Focusing on regulation of inflammatory mediators and apoptosis in cancer. (2010-2014), Principal Investigator, funded by DBT, Gov of India Rs. 25.26 Lakhs.

PUBLICATIONS:

Full length Research Papers in International & national peer reviewed journals:

Pathak, C.; Vaidya, F.U.; Waghela, B.N.; Jaiswara, P.K.; Gupta, V.K.; Kumar, A.; Rajendran, B.K.; Ranjan, K. Insights of Endocytosis Signaling in Health and Disease. Int. J. Mol. Sci. 2023, 24, 2971. https://doi.org/10.3390/ijms24032971 (IF 6.2)
Patel H.S., Shaikh S.J., Ray D., Aswal V.K., Vaidya F., Pathak C., Varade D., Rahdar A., Sharma R.K., (2022) Structural transitions in mixed Phosphatidylcholine/Pluronic micellar systems and their in vitro therapeutic evaluation for poorly water-soluble drug. Journal of Molecular Liquids, 364 (120003) https://doi.org/10.1016/j.molliq.2022.120003. (IF 6.1)
Rawat, S.G., Tiwari, R.K., Jaiswara, P.K., Gupta V.K., Sonker P., Vishvakarma N.K., Kumar S., Pathak C., Gautam V. & Kumar A. (2022) Phosphodiesterase 5 inhibitor sildenafil potentiates the antitumor activity of cisplatin by ROS-mediated apoptosis: a role of deregulated glucose metabolism. Apoptosis. https://doi.org/10.1007/s10495-022-01741-0 (Impact Factor: 5.5).
Singh S., Kishore D., Singh R.K., Pathak C., Ranjan K. (2022) Higher BCG-induced trained immunity prevalence predicts protection from COVID-19: Implications for ongoing BCG trials. Clinical and Translational Discovery, https://doi.org/10.1002/ctd2.60
Patel HS, Shaikh SJ, Ray D, Aswal VK, Vaidya F, Pathak C, Sharma RK. (2022) Formulation, Solubilization, and In Vitro Characterization of Quercetin-Incorporated Mixed Micelles of PEO-PPO-PEO Block Copolymers. Appl Biochem Biotechnol. 194(1):445-463 doi: 10.1007/s12010-021-03691-w. (Impact Factor: 3.0).
Varma R.R., Vaidya, F.U., Pathak, C., Dhaduk,M.P., Dabhi,R.A., Bhatt,B.S., & Patel,M.N. (2021) Synthesis, spectroscopic characterization, computational and biological evaluation of organometallic Re(I) complexes with 5-(2-butyl-5-chloro-1H-imidazol-4-yl)-1,3-diaryl- 4,5-dihydro-1H-pyrazole, Inorganic Chemistry Communications,109005, https://doi.org/10.1016/j.inoche.2021.109005. (Impact Factor: 3.4)
Pansuriya, V. B., Kapadiya, K. M., Rathod, S. L., Prajapati, U. B., Vavaiya, B. M., Padariya, J. B., Vaidya, F. U., Pathak, C., & Parekh, H. M. (2021) “Anti-Cancer Activity of Gabapentin and Chiral Amino Acids-Based Hybrid-Peptides against MCF-7 Breast Cancer Cell-Line”, Journal of Pharmaceutical Research International, 33(46A), 431-446. doi: 10.9734/jpri/2021/v33i46A32886 (Impact Factor: 5.5)
Kanthecha, D. N., Bhatt, B. S., Patel, M. N., Vaidya, F. U., & Pathak, C. (2022). DNA interaction, anticancer, cytotoxicity and genotoxicity studies with potential pyrazine-bipyrazole dinuclear µ-oxo bridged au (III) complexes. Molecular Diversity, 26(4):2085-2101 doi:10.1007/s11030-021-10317-0 Impact Factor: 3.3)
Pursuwani, B. H., Bhatt, B. S., Raval, D. B., Thakkar, V. R., Sharma, J., Pathak, C., & Patel, M. N. (2021). Synthesis, characterization, and biological applications of pyrazole moiety bearing osmium (IV) complexes. Nucleosides, Nucleotides and Nucleic Acids, 40(6), 593-618. doi:10.1080/15257770.2021.1921795 (Impact Factor: 1.4)
Parmar, M.P., Waghela B.N., Vaidya F.U., Pathak C., Parmar, D.V. (2021). “Evaluation of Antimitotic Activity of Herbal Extracts Using Plant-Based Model Systems and Their Cytotoxic Potential against Human Colon Carcinoma Cells”, Journal of Cancer Research and Therapeutics, 17(6):1483-1490 doi:10.4103/jcrt.JCRT_853_19. (Impact Factor: 1.3)
Varma, R. R., Pandya, J. G., Vaidya, F. U., Pathak, C., Dabhi, R. A., Dhaduk, M. P., Bhatt, B.S., Patel, M. N. (2021). DNA interaction, anticancer, antibacterial, ROS and lipid peroxidation studies of quinoxaline-based organometallic re(I) carbonyls. Journal of Molecular Structure, 1240 doi:10.1016/j.molstruc.2021.130529 (Impact Factor: 3.8)
Waghela, B. N., Vaidya, F. U., & Pathak, C. (2021). Upregulation of NOX-2 and Nrf-2 promotes 5-fluorouracil resistance of human colon carcinoma (HCT-116) cells. Biochemistry (Moscow), 86(3), 262-274. doi:10.1134/S0006297921030044 (Impact Factor: 2.8)
Waghela, B. N., Vaidya, F. U., Agrawal, Y., Santra, M. K., Mishra, V., & Pathak, C. (2021). Molecular insights of NADPH oxidases and its pathological consequences. Cell Biochemistry and Function, 39(2), 218-234. doi:10.1002/cbf.3589. (Impact Factor: 3.9)
Gandhi, D. H., Vaidya, F. U., Pathak, C., Patel, T. N., & Bhatt, B. S. (2022). Mechanistic insight of cell anti-proliferative activity of fluoroquinolone drug-based cu (II) complexes. Molecular Diversity, 26, 869–878; doi:10.1007/s11030-021-10199-2 (Impact Factor: 3.3)
Pursuwani, B. H., Bhatt, B. S., Vaidya, F. U., Pathak, C., & Patel, M. N. (2021). Fluorescence, DNA interaction and cytotoxicity studies of 4,5-dihydro-1H-pyrazol-1-yl moiety based os (IV) compounds: Synthesis, characterization, and biological evaluation. Journal of Fluorescence, 31(2), 349-362. doi:10.1007/s10895-020-02657- (Impact Factor: 2.5)
Varma, R. R., Pandya, J. G., Sharma, J., Pathak, C., & Patel, M. N. (2021). DNA interaction, in vivo and in vitro cytotoxicity, reactive oxygen species, lipid peroxidation of –N, S donor re(I) metal complexes. Molecular Diversity, 25(2), 687-699. doi:10.1007/s11030-020-10040-2. (Impact Factor: 3.3)
Jaiswara, P. K., Gupta, V. K., Sonker, P., Rawat, S. G., Tiwari, R. K., Pathak, C., Kumar, S., Kumar, A. (2021). Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. Environmental Toxicology, 36(4), 628-641. doi:10.1002/tox.23067 (Impact Factor: 4.1)
Waghela, B. N., Vaidya, F. U., Ranjan, K., Chhipa, A. S., Tiwari, B. S., & Pathak, C. (2021). AGE-RAGE synergy influences programmed cell death signaling to promote cancer. Molecular and Cellular Biochemistry, 476(2), 585-598. doi:10.1007/s11010-020-03928-y. (Impact Factor: 3.8)
Pursuwani, B. H., Bhatt, B. S., Vaidya, F. U., Pathak, C., & Patel, M. N. (2021). Tetrazolo[1,5-a] quinoline moiety-based os (IV) complexes: DNA binding/cleavage, bacteriostatic and photocytotoxicity assay. Journal of Biomolecular Structure and Dynamics, 39(8), 2894-2903. doi:10.1080/07391102.2020.1756912. (Impact Factor: 4.1)
Bhatt, B. S., Gandhi, D. H., Vaidya, F. U., Pathak, C. , & Patel, M. N. (2021). Cell apoptosis induced by ciprofloxacin based cu(II) complexes: Cytotoxicity, SOD mimic and antibacterial studies. Journal of Biomolecular Structure and Dynamics, 39(12), 4555-4562. doi:10.1080/07391102.2020.1776641. (Impact Factor: 3.3)
Ranjan, K., Waghela, B. N., Vaidya, F. U., & Pathak, C. (2020). Cell-penetrable peptide-conjugated FADD induces apoptosis and regulates inflammatory signaling in cancer cells. International Journal of Molecular Sciences, 21(18), 1-20. doi:10.3390/ijms21186890. (Impact Factor: 5.6)
Vaidya, F. U., Sufiyan Chhipa, A., Mishra, V., Gupta, V. K., Rawat, S. G., Kumar, A., & Pathak, C. (2020). Molecular and cellular paradigms of multidrug resistance in cancer. Cancer Reports, doi:10.1002/cnr2.1291 (Impact Factor: Awaiting)
Pursuwani, B. H., Bhatt, B. S., Vaidya, F. U., Pathak, C., & Patel, M. N. (2020). Synthesis, characterization, and biological evaluation of osmium (IV) pyrazole carbothioamide complexes. Polycyclic Aromatic Compounds, 42 (6):2991-3007 doi:10.1080/10406638.2020.1852581. (Impact Factor: 2.1)
Varma, R. R., Pandya, J. G., Vaidya, F. U., Pathak, C. , Bhatt, B. S., & Patel, M. N. (2020). Biological activities of pyrazoline-indole based re(I) carbonyls: DNA interaction, antibacterial, anticancer, ROS production, lipid peroxidation, in vivo and in vitro cytotoxicity studies. Chemico-Biological Interactions, 330 doi:10.1016/j.cbi.2020.109231. (Impact Factor: 5.1)
Varma, R. R., Pandya, J. G., Vaidya, F. U., Pathak, C., Bhatt, B. S., & Patel, M. N. (2020). Synthesis, characterization, and biological application of pyrazolo[1,5-a]pyrimidine based organometallic re(I) complexes. Acta Chimica Slovenica, 67(3), 957-969. doi:10.17344/acsi.2020.6017 (Impact Factor: 1.7)
Waghela B.N., Vaidya F.U., Gaurav Dave, & Pathak C., (2020). Inhibition of NADPH oxidase activity augments 5-fluorouracil mediated cell Death in human colon carcinoma cells, Int. J. Adv. Res. 8(07), 865-874.
Priyadarshi, K., Shirsath, K., Waghela, N. B., Sharma, A., Kumar, A., & Pathak, C. (2020). Surface modified PAMAM Dendrimers with Gallic acid inhibits, cell proliferation cell migration and inflammatory response to augments apoptotic cell death in human colon carcinoma cells. Journal of Biomolecular Structure & Dynamics, 39: 6853-6869 https://doi.org/10.1080/07391102.2020.1802344 (Impact Factor: 3.3)
Patel, N. J., Bhatt, B. S., Vekariya, P. A., Vaidya, F. U., Pathak, C., Pandya, J., & Patel, M. N. (2020). Synthesis, characterization, structural-activity relationship, and biomolecular interaction studies of heteroleptic pd (II) complexes with acetyl pyridine scaffold. Journal of Molecular Structure, 1221 doi:10.1016/j.molstruc.2020.128802 (Impact Factor: 3.8)
Pursuwani, B. H., Bhatt, B. S., Vaidya, F. U., Pathak, C., & Patel, M. N. (2020). Oxadiazole based os(IV) compounds as potential DNA intercalator and cytotoxic agents. Inorganic Chemistry Communications, 119 doi:10.1016/j.inoche.2020.108070 (Impact Factor: 3.4)
Doshi, P., Bhargava, P., Singh, V., Pathak, C., Joshi, C., & Joshi, M. (2020). Escherichia coli strain engineering for enhanced production of serratiopeptidase for therapeutic applications. International Journal of Biological Macromolecules, 160, 1050-1060. doi:10.1016/j.ijbiomac.2020.05.256 (Impact Factor: 8.0)
Kanthecha, D. N., Bhatt, B. S., Patel, M. N., Raval, D. B., Thakkar, V. R., Vaidya, F. U., & Pathak, C. (2020). Bipyrazole based novel bimetallic µ-oxo bridged au (III) complexes as potent DNA interacalative, genotoxic, anticancer, antibacterial, and cytotoxic agents. Journal of Inorganic and Organometallic Polymers and Materials, 30(12), 5085-5099. doi:10.1007/s10904-020-01618-2 (Impact Factor: 3.5)
Rao, T.S., Mustfa, S.A., Pathak, C., & Ranjan, K. (2019). Cancer Immunotherapy: Future prospective with wide therapeutic spectrum. Cancer Sci Res Open Access 6(2): 1-8. DOI: 10.15226/csroa.2019.00153
Kulkarni P.G., Shah N., Waghela B.N., Pathak C.M., Pappachan A. (2019) Leishmania donovani adenylate kinase 2a prevents ATP-mediated cell cytolysis in macrophages. Parasitology International. 72:101929 https://doi.org/10.1016/j.parint.2019.101929 (Impact Factor: 2.1)
Manglani, K., Vijayan, V., Pathak, C., Khandelwal, M., Singh, P., Chellappa, S., Yadav, V.K., Surolia, A., Gupta, S. (2019). Development and characterization of supramolecular calcitonin assembly and assessment of its interactions with the bone remodelling process. Bone, 122, 123-135. doi:10.1016/j.bone.2019.02.019 (Impact Factor: 4.6)
Mishra, V., & Pathak, C. (2019). Human toll-like receptor 4 (hTLR4): Structural and functional dynamics in cancer. International Journal of Biological Macromolecules, 122, 425-451. doi:10.1016/j.ijbiomac.2018.10.142 (Impact Factor: 8.0)
Vaidya, F. U., Sharma, R., Shaikh, S., Ray, D., Aswal, V. K., & Pathak, C. (2019). Pluronic micelles encapsulated Curcumin manifests apoptotic cell death and inhibits pro-inflammatory cytokines in Human breast adenocarcinoma cells. Cancer Reports, 2:1-e1133. https://doi.org/10.1002/cnr2.1133 (Impact Factor: Awaiting)
Mishra, V., & Pathak, C. (2019). Structural insights into pharmacophore assisted in silico identification of protein-protein interaction inhibitors for inhibition of human Toll-like receptor 4 – myeloid differentiation factor-2 (hTLR4−MD-2) complex. Journal of Biomolecular Structure and Dynamics. 37:1968-1991 DOI: 10.1080/07391102.2018.1474804 (Impact Factor: 3.3)
Patel, S., Waghela, B., Shah, K., Vaidya, F., Mirza, S., Patel, S., Pathak C., & Rawal, R. (2018). Silibinin, A Natural Blend in Polytherapy Formulation for Targeting Cd44v6 Expressing Colon Cancer Stem Cells. Scientific Reports, 8(1):16985 doi:10.1038/s41598-018-35069-0 (Impact Factor: 4.9)
Pandey, S. S., Singh, S., Pathak, C., & Tiwari, B. S. (2018). Programmed Cell Death: A Process of Death for Survival” – How Far Terminology Pertinent for Cell Death in Unicellular Organisms. Journal of Cell Death, 11:1-4 doi:10.1177/1179066018790259
Lunagariya, M. V., Thakor, K. P., Waghela, B. N., Pathak, C., & Patel, M. N. (2018). Design, synthesis, pharmacological evaluation, and DNA interaction studies of binuclear pt (II) complexes with pyrazolo[1,5-a]pyrimidine scaffold. Applied Organometallic Chemistry, 3232 (4) e4222 doi:10.1002/aoc.4222 (Impact Factor: 4.1)
Lunagariya, M. V., Thakor, K. P., Varma, R. R., Waghela, B. N., Pathak, C., & Patel, M. N. (2018). Synthesis, characterization, and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum (II) complexes. MedChemComm, 9(2), 282-298. doi:10.1039/c7md00472a (Impact Factor: 4.1)
Lunagariya, M. V., Thakor, K. P., Waghela, B. N., Vaidya, F. U., Pathak, C., & Patel, M. N. (2018). Design, synthesis, MTT assay, DNA interaction studies of platinum (II) complexes. Journal of Biomolecular Structure and Dynamics, 36(1), 14-31. doi:10.1080/07391102.2016.1268071 (Impact Factor: 3.3)
Kumar, M., Ranjan, K., Singh, V., Pathak, C., Pappachan, A., & Singh, D. D. (2017). Hydrophilic Acylated Surface Protein A (HASPA) of Leishmania donovani: Expression, purification, and Biophysico-Chemical Characterization. Protein J. 36(4):343-351, doi 10.1007/s10930-017-9726-x (Impact Factor: 3.0)
Ranjan, K., & Pathak, C. (2016). Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death. Molecular and Cellular Biochemistry 422(1-2):135-150, doi:10.1007/s11010-016-2813-z (Impact Factor: 3.8)
Ranjan, K., & Pathak, C. (2016). FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Scientific Reports. 6:22787 doi:10.1038/srep22787. (Impact Factor: 4.9)
Ranjan, K., & Pathak, C. (2016). Expression of cFLIPL determines the basal interaction of Bcl-2 with Beclin-1 and regulates p53 dependent ubiquitination of Beclin-1 during autophagic stress. Journal of Cellular Biochemistry, 117(8):1757-1768. doi:10.1002/jcb.25474 (Impact Factor: 4.4)
Dhumale, S. S., Waghela, B. N., & Pathak, C. (2015). Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB Life, 67(5):361-73, doi:10.1002/iub.1379(Impact Factor: 4.7)
Waghela, B. N., Sharma, A., Dhumale, S., Pandey, S. M., & Pathak, C. (2015). Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity, and apoptosis in human colon carcinoma cells. PLoS ONE, 10(2) e0117526. doi:10.1371/journal.pone.0117526 (Impact Factor: 3.7)
Pathak, C., Ranjan Singh, R., Yadav, S., Kapoor, N., Raina, V., Gupta, S., & Surolia, A. (2014). Evaluation of Benzothiophene carboxamides as analgesics and anti-inflammatory agents. IUBMB Life, 66(3), 201-211. doi:10.1002/iub.1252 (Impact Factor: 4.7)
Ranjan, K., Sharma, A., Surolia, A., & Pathak, C. (2014). Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. BioFactors, 40(1), 157-169. doi:10.1002/biof.1098 (Impact Factor: 6.4)
Ranjan, K., Surolia, A., & Pathak, C. (2012). Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. Journal of Cell Communication and Signaling, 6(3), 155-168. doi:10.1007/s12079-012-0166-2 (Impact Factor: 5.9)
Vinayak, M., & Pathak, C. (2010). Queuosine modification of tRNA: Its divergent role in cellular machinery. Bioscience Reports, 30(2), 135-148. doi:10.1042/bsr20090057 (Impact Factor: 3.9)
Pathak, C., Jaiswal, Y. K., & Vinayak, M. (2008). Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer. Bioscience Reports, 28(2), 73-81. doi:10.1042/BSR20070011 (Impact Factor: 3.9)
Pathak, C., Jaiswal, Y. K., & Vinayak, M. (2008). Modulation in the activity of lactate dehydrogenase and level of c-myc and c-fos by modified base queuine in cancer. Cancer Biology and Therapy, 7(1), 85-91. doi:10.4161/cbt.7.1.5133 (Impact Factor: 4.8)
Pathak, C., Jaiswal, Y. K., & Vinayak, M. (2008). Queuine mediated inhibition in phosphorylation of tyrosine phosphoproteins in cancer. Molecular Biology Reports, 35(3), 369-374. doi:10.1007/s11033-007-9095-1 (Impact Factor: 2.7)
Pathak, C., Jaiswal, Y. K., & Vinayak, M. (2007). Possible involvement of queuine in regulation of cell proliferation. BioFactors, 29(4), 159-173. doi:10.1002/biof.5520290401. (Impact Factor: 6.4)
Pathak, C., Jaiswal, Y. K., & Vinayak, M. (2005). Hypomodification of transfer RNA in cancer with respect to queuosine. RNA Biology, 2(4), 143-148. doi:10.4161/rna.2.4.2417 (Impact Factor: 4.7)
Pathak, C., & Vinayak, M. (2005). Modulation of lactate dehydrogenase isozymes by modified base queuine. Molecular Biology Reports, 32(3), 191-196. doi:10.1007/s11033-004-6941-2. (Impact Factor: 2.7)

PATENTS:

Pathak C., Mishra V., Tiwari S., Waghela B.N., Vaidya F.U., Kapoor N., Kumar D.; “Novel Caffeic Acid Analogsas Toll-like receptor 4 Antagonists” Indian patent filed, 27th Sept 2019. Application No. 201921039249
Surolia A., Pathak C., Kapoor N., Raina V., Gupta S. (2013) Benzothiophene Carboxamide compounds, composition, and applications thereof. Application No.1646/DEL/2010 A; Date of filing of Application: 14/07/2010; Publication Date: 18/10/2013; The Patent Office Journal 42/2013.

BOOK CHAPTERS:

Pathak C., Vaidya F.U., Waghela B.N., Chhipa A.S., Tiwari, B.S. & Ranjan K. (2021) Advanced glycation end products mediated oxidative stress and regulated cell death signalling in cancer; Sajal Chakrborty (Eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. 535-550, Springer-Nature, DOI: 10.1007/978-981-15-4501-6_44-1, ISBN 978-981-15-4501-6
Vaidya F.U., Chhipa A.S., Sagar N., Pathak C. (2020) Oxidative Stress and Inflammation Can Fuel Cancer. In: Maurya P., Dua K. (eds) Role of Oxidative Stress in Pathophysiology of Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-1568-2_14. ISBN: 978-981-15-1567-5
Pathak C, Vaidya F.U. & Pandey, S.M. (2019) Mechanism for Development of Nanobased Drug Delivery System. In Mohapatra et al. (Eds) Applications of Targeted Nano Drugs and Delivery Systems Nanoscience and Nanotechnology in Drug Delivery: A volume in Micro and Nano Technologies. Elsevier, https://doi.org/10.1016/C2017-0-00274-4; ISBN 978-0-12-814029-1.
Maurya, V. K., Kumar, D., Pathak, C., & Tiwari, B. S. (2018) Involvement of Reactive Species of Oxygen and Nitrogen in Triggering Programmed Cell Death in Plants. In: Vats S. (eds) Biotic and Abiotic Stress Tolerance in Plants. pp. 257-278, Springer, Singapore https://doi.org/10.1007/978-981-10-9029-5_10 ISBN 978-981-10-9028-8
Sharma R.K. & Pathak C. (2014). A Novel Lamotrigine-Loaded Nanoparticles using PEO-PPO-PEO Tri-block Copolymers. Nanotechnology: Novel Perspectives and Prospects. McGrew Hill, New Delhi; 898-906 ISBN: 13:978-93-392-2109-6

LINKED PROFILE - linkedin.com/in/himanshurgupta

ORCID ID - https://orcid.org/0000-0003-2354-9314

AFFILIATIONS:
ZEBCOG-Zebrafish Centre of Excellence, MGMIHS

SCEINTIFIC PROFILE:

Assistant professor in the department of Medical Biotechnology at MGM school of Biomedical sciences, which is a constituent unit of Mahatma Gandhi Missions Institute of Health Sciences, Navi Mumbai.

Long term interests are in Molecular research and research in the field of Genetics. My research focuses on developmental genetics related to Zebrafish (danio rerio). Hold a graduate degree from Mumbai University and Post graduate degree and doctoral degree from the Mahatma Gandhi Missions Institute of Health Sciences, Navi Mumbai in Medical Genetics. PhD topic was “Studies On The Mechanism Of Action Of Homeopathic Drugs On Osteoporosis In Zebra Fish Model”.

DEVELOPMENTAL EXPERIENCE AND ACTIVITIES:

Expertise in subjects like Molecular biology, Analytical instrumentation, Recombinant DNA Technology, Immunology & Immunogenetics, Bioinformatics, clinical, developmental and environmental genetics, research methodology and scientific writing.

For about 4 years have worked on a BRNS (Board of research in Nuclear science- a BARC division)nsored project as a research fellow

Actively engaged as a faculty for Post graduate and Ph.D. scholars. In addition, actively engaged in basic research using Zebrafish as an animal model, taking up various projects and training programs on Zebrafish

Have undergone several trainings and faculty developmental programs in zebrafish and Molecular techniques in addition to academic trainings

PROJECTS /EXTRAMURAL FUNDING

Sanctioned project - “Hands-on Training Programme on Zebrafish in Biomedical Research and Drug Development” from Department of Health Research (DHR-ICMR) under Ministry of Health & Family Welfare for Rs. 44 Lakhs

PATENT

Joint patent holder for published patent entiled “A Biological Safety Cabinet And A Kit Thereof” numbered 201721023794

COPYRIGHTS PUBLISHED:

16 published
07 applied

LIST OF PUBLICATIONS:

Hingu B, Sake S, Gupta H, Vyas N, Thakur KS, Thakur M. Study on the phytochemical,
antioxidant and in vitro anticancer activity on root extract of Simarouba glauca DC. Plant
Science Today. 2023;
Philip ST, Thimmapuram J, Gupta H, Fatima TH, Rahate S, Yeram N, Thakur K, Thakur M.
An Experimental Prospective Study on Effectiveness of Brief Heartfulness-Based Start ‘U’p
Program on Anxiety and Perceived Stress in Allied Health Students. Journal of Health and
Allied Sciences NU. 2023 May 1.
Jadhav SR, Thakur M, Gupta H. Biosynthesis of silver nanoparticles using mushroom extract
and its toxicity assessement in zebrafish embryos. Vegetos. 2023 Mar;36(1):119-26.
Chapter published - Gupta H, Kadam N, Patil S, Thakur M. Homeopathy as a Nanomedicine:
A Scientific Approach. InEngineered Nanomaterials for Innovative Therapies and Biomedicine
2022 Feb 21 (pp. 405-424). Cham: Springer International Publishing.
A. K. Agrawal, M. Thakur, H. Gupta, B. Singh, P. Singhai, V. K. Suri, Y. S. Kashyap, and M.
Shukla. Feasibility of osteoporosis studies in zebrafish model using SR-microCT. AIP
Conference Proceedings .2020;2265: 030033.
Thakur K, Mol PM, Gawhankar M, Gupta H, Patil P, Thakur M. Physicochemical
characterization and antimicrobial properties of Mahamanjishthadi kadhafi: An Ayurvedic
formulation. Annals of Phytomedicine. 2020;9(1):78-90.
Himanshu G, Mansee T. Evaluation of homeopathic drugs on glucocorticoid induced
osteoporosis (GIOP) zebrafish model. Asian Journal of Bio Science. 2018;13(1):32-8.
Gupta H, Singh D, Vanage G, Joshi DS, Thakur M. Evaluation of histopathological and
ultrastructural changes in the testicular cells of Wistar rats post chronic exposure to gold
nanoparticles.2018.
Book Published - Reproductive Toxicity assessment of Gold and Silver Nanoparticle, LAP
Lambert Academic Publishing ( 2018-03-09 ), ISBN-13: 978-613-8-33994-6, ISBN-10:
6138339940
Gupta HR, Patil Y, Singh D, Thakur M. Embryonic Zebrafish Model-A Well-Established
Method for Rapidly Assessing the Toxicity of Homeopathic Drugs:-Toxicity Evaluation of
Homeopathic Drugs Using Zebrafish Embryo Model. Journal of pharmacopuncture. 2016
Dec;19(4):319.
International Conference paper presented in the year 2016 at the Techno Societal conferene
Pandarpur
Thakur M, Gupta H, Singh D, Mohanty IR, Maheswari U, Vanage G, Joshi DS.
Histopathological and ultra structural effects of nanoparticles on rat testis following 90 days
(Chronic study) of repeated oral administration. Journal of nanobiotechnology. 2014
Oct;12(1):1-3.

STUDENTS GUIDED FOR MSC DISSERTATIONS:

26 students

CONSULTANCY / EXTERNAL STUDENTS TRAINED IN ZEBRAFISH:

2021-22 – 04 nos of students - Revenue generated – Rs. 19,500/-
2022-23 – 24 nos of students – Revenue generated – Rs. 1,12,500 /-
2023-24 – 05 nos of students (April to June ‘23) – Rs. 25,000/-

ADDITIONAL EXPERIENE:

1998 to 2010 – Have an experience of more than 12 years in International Shipping Industry where I have worked as Client Support and Export Documentation Manager in companies like - Hapag Lloyd, German Express & Forbes Patvolk.

Designation:

Dr. Yogesh Navalsing Patil, working as a Senior Tutor, in Department of Medical Biotechnolgy, MGM School of Biomedical Sciences, Kamothe, Navi Mumbai.

Research Interest :

Development of India Specific low cost Medical Devices for screening and diagnosis of Infectious Diseases.

Educational Background:

Ph.D Medical Biotechnology (2022), MGM Institute of Health Sciences, Navi Mumbai.

M.Sc Biotechnology, BAMU University, Sambhajinagar.

B.E Biotechnology (2015), University of Mumbai.

Work Experience:

Senior Tutor, (Medical Biotechology and Genetics) MGM School of Biomedical Science. January, 2023 till Present.

Tutor (Medical Biotechnology and Genetics) MGM School of Biomedical Sciences, 5 Years (2017 – 2022)

Junior Research Fellow on BRNS (DAE) Funded Project, MGM School of Biomedical Sciences, 2 Years ( 2015 – 2017)

Patents Granted:

Indian Patent: “SENSOR BASED INFLATABLE DEVICE” Application No.: 201721023124 Inventors: V.K.Suri, Santosh Narayan Khedkar, Indra Vijay Singh, Nakka Muralidhara Rao, Yogesh Patil, Sudhirchandra Kadam, Mansee Thakur.
Indian Design Patent: “BioMol Seperator” Regestration No. 318667-001 Date of Filling: 12/06/2019 Inventors: V.K.Suri, Mansee Thakur, Yogesh Patil, B.P.Ronge, P.M.Pawar.

Patents Filled:

A BIOLOGICAL SAFETY CABINET AND A KIT THEREOF; ApplicationNumber 201721023794 A; Publication Date: 11/01/2019 . Inventors : V.K.Suri, Mansee Thakur, Santosh Narayan Khedkar, Nakka Muralidhara Rao, Yogesh Patil, Himanshu Gupta, Sudhirchandra Kadam, Prajyot P. Shriram, Bharadwaj S. Dogga, Harpreet Singh Chhabra, Prashant R. Chavan.

Extramural projects received for funding:

Molecular Diagnostics of Infectious Diseases – Let’s analyze the nucleic acid of Pathogens. Role: Co-PI

Project Sanctioned Amount : 42, 43,950 /-
Project Duration : 5 Years

Copyrights Registered:

“Low Cost Indigenous Dna Detection System” Dairy No. L 104314/2021
Authors: Yogesh Patil, Mansee Thakur
“Development Of Fam Probe Based Asssay For Detection Of Uropathogenic E.Coli on LFDS”
Authors: Mansee Thakur, Sharvari Samant, Yogesh Patil, Raj Vashi
“Development Of Fam Probe Based Asssay For Detection Of S Aureus on LFDS”
Authors: Mansee Thakur, Sharvari Samant, Yogesh Patil, Madhu Singh
“Development of PCR Based Assay For Detection of Bacterial Blight of Pomegranate” Authors: Yogesh Patil Dr.Mansee Thakur Tarun Parihar
“Validation Studies of Custom Built MGM Biosafety Cabinet” Authors: Yogesh Patil, Dr.Mansee Thakur, Shaila Kotkar

Publications :

Patil Yogesh, and Mansee Thakur. "Development and validation of indigenously developed DNA detection system for M. tuberculosis." International Journal on Emerging Technologies, 11 (13) : 182-187 (2020).
Yogesh Patil, Vinod Suri, Aseem Suri, Harapriya Kar, Mansee Thakur. Development of Low Cost PCR Product Detection System for Screening and Diagnosis of Infectious Diseases. InTechno- Societal 2020 2021 (pp. 923-933). Springer, Cham.
Kar H, Pachpute S, Patil P, Patil Y, Urhekar AD. Role of Gene Xpert in Early Diagnosis and Treatment of Tuberculosis. InTechno-Societal 2016, InternationalConference on Advanced Technologies for Societal Applications 2016 Dec 20 (pp. 623-627). Springer, Cham.
Gupta HR, Patil Y, Singh D, Thakur M. Embryonic Zebrafish Model-A Well- Established Method for Rapidly Assessing the Toxicity of Homeopathic Drugs:-Toxicity Evaluation of Homeopathic Drugs Using Zebrafish Embryo Model. Journal of Pharmacopuncture. 2016 Dec;19(4):319.
Parihar T, Patil Y, Thakur M. Development of polymerase chain reaction based assay for diagnosisof bacterial blight of pomegranate. Journal of Advanced Scientific Research. 2021 Aug 13;2021(HBIA):05-9.
Thakur M, Patil Y, Philip ST, Hamdule T, Thimmapuram J, Vyas N, Thakur K. Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length. Frontiers in Psychology. 2023 Jun 5;14:1158760.

Startups Initiated:

BioMol Seperator - Incubated under MGM Innovation and Incubation Center (Promoters – Yogesh Patil, Mansee Thakur, Tarun Parihar)
Portable Biosafety Cabinet - Incubated under MGM Innovation and Incubation Center (Promoters –Mansee Thakur, Yogesh Patil Shaila Kotkar)
MGM Vaccume Dressing System - Incubated under MGM Innovation and Incubation Center (Promoters – Yogesh Patil, Mansee Thakur)

Area of interest for Research and Development:

Key Interest: Development & Deployment of Low cost India specific TB Detection system

Development of low cost alternate solutions in the field of:

Molecular Diagnostics
Molecular Biology
Molecular Immunology
Molecular Microbiology
Mammalian cell culture
Plant tissue culture

Awards Received :

Received Best Paper Award in the International conference on Technologies for future cities organized by Pillais college of Engineering, Navi Mumbai ( Oct 2021) in the track “Healthcare for future cities ” for the paper presented with title “Evaluation of Indigenous Detection system for detection of LAMP-Amplified Products of Mycobacterium tuberculosis”
Received Brand Ambassador award for participating in certificate course on “Startup, Innovation and IPR” organized by Hansraj College and Patlex Business solution, Delhi (Sept 2021)
Bio-Entrepreneurship Second runner-up Award for presenting the innovative idea on “Portable DNA Detection System” in TSEC college of Engineering (Feb 2020)
Best oral and Poster presentation award- First Rank on topic “Design and development of TBDetection system” in National Conference on Tuberculosis organized by MGM-IHS, Kamothe, Navi Mumbai-410209”
Best poster presentation award Third Rank on Vaccume Dressing system presented on National Sciences Day organized by MGM-IHS, Kamothe, Navi Mumbai-410209
Best poster presentation award on “Design and Development of MGM Vaccume DressingSystem” First Rank in National Facets of Life Sciences organized by Department of Biotechnology University of Mumbai
Best poster presentation award on “Design and Development of Portable Biological safetycabinet” Third Rank in National Facets of Life Sciences organized by Department of Biotechnology University of Mumbai

Faculty & Staff

Teaching Faculty

Dr. Mansee Thakur

Professor & HOD

Dr. Chandramani Pathak

Dr. Raman P. Yadav

Dr. Himanshu Gupta

Dr. Priyanka Pareek

Dr. Yogesh Patil

Dr. Neelam Yeram

Mr. Rohit I. Gupta

Ms. Rafiya Sangameshwari

Mrs. Anamika Mahesh Chalwadi

Mr. Pratik Morade

Mr. Subodh Rahate

Ms. Chandana Kulkarni

Mrs. Priyanka Rathod

Ms. Pranita Utekar

Ms. Shruti Patil

Non-Teaching Faculty

Visiting Faculty

Faculty 2021-22